Functional correlates of pallidal stimulation for Parkinson's disease
Identifieur interne : 003006 ( Main/Corpus ); précédent : 003005; suivant : 003007Functional correlates of pallidal stimulation for Parkinson's disease
Auteurs : Masafumi Fukuda ; Marc Mentis ; Maria Felice Ghilardi ; Vijay Dhawan ; Angelo Antonini ; John Hammerstad ; Andres M. Lozano ; Anthony Lang ; Kelly Lyons ; William Koller ; Claude Ghez ; David EidelbergSource :
- Annals of Neurology [ 0364-5134 ] ; 2001-02-01.
Abstract
We measured regional cerebral blood flow with H215O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, p < 0.002) and reduced timing errors (movement onset time, 55%, p < 0.01) as well as spatial errors (10%, p < 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. Ann Neurol 2001:49:155–164
Url:
DOI: 10.1002/1531-8249(20010201)49:2<155::AID-ANA35>3.0.CO;2-9
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Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, p < 0.002) and reduced timing errors (movement onset time, 55%, p < 0.01) as well as spatial errors (10%, p < 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. Ann Neurol 2001:49:155–164</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Masafumi Fukuda MD</name><affiliations><json:string>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</json:string><json:string>New York University School of Medicine, New York, NY</json:string></affiliations></json:item><json:item><name>Marc Mentis MD</name><affiliations><json:string>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</json:string><json:string>New York University School of Medicine, New York, NY</json:string></affiliations></json:item><json:item><name>Maria Felice Ghilardi MD</name><affiliations><json:string>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</json:string></affiliations></json:item><json:item><name>Vijay Dhawan PhD</name><affiliations><json:string>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</json:string><json:string>New York University School of Medicine, New York, NY</json:string></affiliations></json:item><json:item><name>Angelo Antonini MD</name><affiliations><json:string>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</json:string><json:string>New York University School of Medicine, New York, NY</json:string></affiliations></json:item><json:item><name>John Hammerstad MD</name><affiliations><json:string>Department of Neurology, Oregon Health Science University, Portland, OR</json:string></affiliations></json:item><json:item><name>Andres M. Lozano MD, PhD</name><affiliations><json:string>The Toronto Western Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Anthony Lang MD</name><affiliations><json:string>The Toronto Western Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Kelly Lyons PhD</name><affiliations><json:string>University of Miami Medical Center, Miami, FL</json:string></affiliations></json:item><json:item><name>William Koller MD, PhD</name><affiliations><json:string>University of Miami Medical Center, Miami, FL</json:string></affiliations></json:item><json:item><name>Claude Ghez MD</name><affiliations><json:string>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</json:string></affiliations></json:item><json:item><name>David Eidelberg MD</name><affiliations><json:string>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</json:string><json:string>New York University School of Medicine, New York, NY</json:string></affiliations></json:item></author><articleId><json:string>ANA35</json:string></articleId><language><json:string>eng</json:string></language><abstract>We measured regional cerebral blood flow with H215O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, p > 0.002) and reduced timing errors (movement onset time, 55%, p > 0.01) as well as spatial errors (10%, p > 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. 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Kerr Fellowship of the Parkinson Disease Foundation</note><note>Cotzias Fellowship of the American Parkinson Disease Association</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Functional correlates of pallidal stimulation for Parkinson's disease</title><author><persName><forename type="first">Masafumi</forename><surname>Fukuda</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation></author><author><persName><forename type="first">Marc</forename><surname>Mentis</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation></author><author><persName><forename type="first">Maria Felice</forename><surname>Ghilardi</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</affiliation></author><author><persName><forename type="first">Vijay</forename><surname>Dhawan</surname></persName><roleName type="degree">PhD</roleName><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation></author><author><persName><forename type="first">Angelo</forename><surname>Antonini</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation></author><author><persName><forename type="first">John</forename><surname>Hammerstad</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Oregon Health Science University, Portland, OR</affiliation></author><author><persName><forename type="first">Andres M.</forename><surname>Lozano</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Toronto Western Hospital, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Anthony</forename><surname>Lang</surname></persName><roleName type="degree">MD</roleName><affiliation>The Toronto Western Hospital, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Kelly</forename><surname>Lyons</surname></persName><roleName type="degree">PhD</roleName><affiliation>University of Miami Medical Center, Miami, FL</affiliation></author><author><persName><forename type="first">William</forename><surname>Koller</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>University of Miami Medical Center, Miami, FL</affiliation></author><author><persName><forename type="first">Claude</forename><surname>Ghez</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</affiliation></author><author><persName><forename type="first">David</forename><surname>Eidelberg</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Center for Neuroscience Research, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030</p></note><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation></author></analytic><monogr><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="DOI">10.1002/(ISSN)1531-8249</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-02-01"></date><biblScope unit="volume">49</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="155">155</biblScope><biblScope unit="page" to="164">164</biblScope></imprint></monogr><idno type="istex">B3A3C7D6767749500F80C7071B4F35AC2BD9D124</idno><idno type="DOI">10.1002/1531-8249(20010201)49:2<155::AID-ANA35>3.0.CO;2-9</idno><idno type="ArticleID">ANA35</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We measured regional cerebral blood flow with H215O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, p < 0.002) and reduced timing errors (movement onset time, 55%, p < 0.01) as well as spatial errors (10%, p < 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. 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York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8249</doi><issn type="print">0364-5134</issn><issn type="electronic">1531-8249</issn><idGroup><id type="product" value="ANA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="ANNALS OF NEUROLOGY">Annals of Neurology</title><title type="subtitle">Official Journal of the American Neurological Association and the Child Neurology Society</title><title type="short">Ann Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/1531-8249(20010201)49:2<>1.0.CO;2-Y</doi><numberingGroup><numbering type="journalVolume" number="49">49</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2001-02-01">1 February 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="35" status="forIssue"><doi origin="wiley" registered="yes">10.1002/1531-8249(20010201)49:2<155::AID-ANA35>3.0.CO;2-9</doi><idGroup><id type="unit" value="ANA35"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2001 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2000-06-07"></event><event type="manuscriptRevised" date="2000-09-13"></event><event type="manuscriptAccepted" date="2000-09-13"></event><event type="firstOnline" date="2001-02-07"></event><event type="publishedOnlineFinalForm" date="2001-02-07"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.1 mode:FullText source:FullText result:FullText" date="2010-02-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">155</numbering><numbering type="pageLast">164</numbering></numberingGroup><correspondenceTo>Center for Neuroscience Research, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANA.ANA35.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="30"></count><count type="wordTotal" number="6702"></count></countGroup><titleGroup><title type="main" xml:lang="en">Functional correlates of pallidal stimulation for Parkinson's disease</title><title type="short" xml:lang="en">PET Correlates of Motor Improvement with GPi DBS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Masafumi</givenNames><familyName>Fukuda</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Marc</givenNames><familyName>Mentis</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Maria Felice</givenNames><familyName>Ghilardi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Vijay</givenNames><familyName>Dhawan</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Angelo</givenNames><familyName>Antonini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>John</givenNames><familyName>Hammerstad</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Andres M.</givenNames><familyName>Lozano</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Anthony</givenNames><familyName>Lang</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Kelly</givenNames><familyName>Lyons</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af6"><personName><givenNames>William</givenNames><familyName>Koller</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Claude</givenNames><familyName>Ghez</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>David</givenNames><familyName>Eidelberg</familyName><degrees>MD</degrees></personName><contactDetails><email>david1@nshs.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>New York University School of Medicine, New York, NY</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Oregon Health Science University, Portland, OR</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="CA" type="organization"><unparsedAffiliation>The Toronto Western Hospital, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>University of Miami Medical Center, Miami, FL</unparsedAffiliation></affiliation></affiliationGroup><fundingInfo><fundingAgency>National Institutes of Health</fundingAgency><fundingNumber>NS RO1 35069</fundingNumber><fundingNumber>NS KO8 01961</fundingNumber><fundingNumber>NS K24 02101</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Parkinson Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Veola T. Kerr Fellowship of the Parkinson Disease Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Cotzias Fellowship of the American Parkinson Disease Association</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We measured regional cerebral blood flow with H<sub>2</sub><sup>15</sup>O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, <i>p</i> < 0.002) and reduced timing errors (movement onset time, 55%, <i>p</i> < 0.01) as well as spatial errors (10%, <i>p</i> < 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. Ann Neurol 2001:49:155–164</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Functional correlates of pallidal stimulation for Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>PET Correlates of Motor Improvement with GPi DBS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Functional correlates of pallidal stimulation for Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Masafumi</namePart><namePart type="family">Fukuda</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Mentis</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria Felice</namePart><namePart type="family">Ghilardi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vijay</namePart><namePart type="family">Dhawan</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angelo</namePart><namePart type="family">Antonini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Hammerstad</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Oregon Health Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres M.</namePart><namePart type="family">Lozano</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Toronto Western Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony</namePart><namePart type="family">Lang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>The Toronto Western Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kelly</namePart><namePart type="family">Lyons</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Miami Medical Center, Miami, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William</namePart><namePart type="family">Koller</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>University of Miami Medical Center, Miami, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claude</namePart><namePart type="family">Ghez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Neurobiology and Behavior, Motor Control Laboratory, Columbia College of Physicians and Surgeons, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Eidelberg</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Neurosciences, North Shore‐Long Island Jewish Research Institute, Manhasset, NY</affiliation><affiliation>New York University School of Medicine, New York, NY</affiliation><description>Correspondence: Center for Neuroscience Research, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-02-01</dateIssued><dateCaptured encoding="w3cdtf">2000-06-07</dateCaptured><dateValid encoding="w3cdtf">2000-09-13</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent><extent unit="references">30</extent><extent unit="words">6702</extent></physicalDescription><abstract lang="en">We measured regional cerebral blood flow with H215O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, p < 0.002) and reduced timing errors (movement onset time, 55%, p < 0.01) as well as spatial errors (10%, p < 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. Ann Neurol 2001:49:155–164</abstract><note type="funding">National Institutes of Health - No. NS RO1 35069; No. NS KO8 01961; No. NS K24 02101; </note><note type="funding">National Parkinson Foundation</note><note type="funding">Veola T. Kerr Fellowship of the Parkinson Disease Foundation</note><note type="funding">Cotzias Fellowship of the American Parkinson Disease Association</note><relatedItem type="host"><titleInfo><title>Annals of Neurology</title><subTitle>Official Journal of the American Neurological Association and the Child Neurology Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>155</start><end>164</end><total>10</total></extent></part></relatedItem><identifier type="istex">B3A3C7D6767749500F80C7071B4F35AC2BD9D124</identifier><identifier type="DOI">10.1002/1531-8249(20010201)49:2<155::AID-ANA35>3.0.CO;2-9</identifier><identifier type="ArticleID">ANA35</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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